Nalaganje...
Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol
BACKGROUND: A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution. Mutational obliteration of the monastrol binding site results in a monastrol-resistant, but otherwise catalytically activ...
Shranjeno v:
| Main Authors: | , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2006
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1448180/ https://ncbi.nlm.nih.gov/pubmed/16504166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-6-2 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|