Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids

O-GlcNAc transferase (OGT) attaches a GlcNAc moiety on specific substrate proteins using UDP-GlcNAc as the sugar donor. This modification can alter protein function by regulating cellular signaling and transcription pathways in response to altered nutrient availability and stress. Specific inhibitor...

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發表在:Medchemcomm
Main Authors: Zhang, Hao, Tomašič, Tihomir, Shi, Jie, Weiss, Matjaž, Ruijtenbeek, Rob, Anderluh, Marko, Pieters, Roland J.
格式: Artigo
語言:Inglês
出版: Royal Society of Chemistry 2018
主題:
Chemistry
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072325/
https://ncbi.nlm.nih.gov/pubmed/30108977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00115d
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