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New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins. OGT is a promising target in various pathologies...
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| Publicado no: | Front Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8079942/ https://ncbi.nlm.nih.gov/pubmed/33937202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.666122 |
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