New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth

O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins. OGT is a promising target in various pathologies...

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Udgivet i:Front Chem
Main Authors: Weiss, Matjaž, Loi, Elena M., Sterle, Maša, Balsollier, Cyril, Tomašič, Tihomir, Pieters, Roland J., Gobec, Martina, Anderluh, Marko
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079942/
https://ncbi.nlm.nih.gov/pubmed/33937202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.666122
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