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Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition

O-GlcNAcylation is an essential post-translational modification that occurs on nuclear and cytoplasmic proteins, regulating their function in response to cellular stress and altered nutrient availability. O-GlcNAc transferase (OGT) is the enzyme that catalyzes this reaction and represents a potentia...

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發表在:Molecules
Main Authors: Loi, Elena Maria, Weiss, Matjaž, Pajk, Stane, Gobec, Martina, Tomašič, Tihomir, Pieters, Roland J., Anderluh, Marko
格式: Artigo
語言:Inglês
出版: MDPI 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7436030/
https://ncbi.nlm.nih.gov/pubmed/32722493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25153381
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