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Elucidating the Protein Substrate Recognition of O-GlcNAc Transferase (OGT) Toward O-GlcNAcase (OGA) Using a GlcNAc Electrophilic Probe

The essential human O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole enzyme responsible for modifying thousands of intracellular proteins with the monosaccharide O-GlcNAc. This unique modification plays crucial roles in human health and disease, but the substrate recognition o...

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書目詳細資料
發表在:Int J Biol Macromol
Main Authors: Kositzke, Adam, Fan, Dacheng, Wang, Ao, Li, Hao, Worth, Matthew, Jiang, Jiaoyang
格式: Artigo
語言:Inglês
出版: 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856287/
https://ncbi.nlm.nih.gov/pubmed/33333092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijbiomac.2020.12.078
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