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Recognition of diazirine-modified O-GlcNAc by human O-GlcNAcase

The mammalian O-GlcNAc hydrolase (OGA) removes O-GlcNAc from serine and threonine residues on intracellular glycoproteins. OGA activity is sensitive to N-acyl substitutions to O-GlcNAc, with alkyl diazirine-modified O-GlcNAc (O-GlcNDAz) being completely resistant to removal by OGA. Using homology mo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rodriguez, Andrea C., Kohler, Jennifer J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109824/
https://ncbi.nlm.nih.gov/pubmed/25068034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00164H
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