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Recognition of diazirine-modified O-GlcNAc by human O-GlcNAcase
The mammalian O-GlcNAc hydrolase (OGA) removes O-GlcNAc from serine and threonine residues on intracellular glycoproteins. OGA activity is sensitive to N-acyl substitutions to O-GlcNAc, with alkyl diazirine-modified O-GlcNAc (O-GlcNDAz) being completely resistant to removal by OGA. Using homology mo...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109824/ https://ncbi.nlm.nih.gov/pubmed/25068034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00164H |
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