Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential human glycosyltransferase that adds O-GlcNAc modifications on numerous proteins. However, little is known about how OGT recognizes various protein substrates. Here we report GlcNAc electrophilic probes (GEPs) to expedite the...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Hu, Chia-Wei, Worth, Matthew, Fan, Dacheng, Li, Baobin, Li, Hao, Lu, Lei, Zhong, Xiaofang, Lin, Ziqing, Wei, Liming, Ge, Ying, Li, Lingjun, Jiang, Jiaoyang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698155/
https://ncbi.nlm.nih.gov/pubmed/29058723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2494
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