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Targeted Covalent Inhibition of O-GlcNAc Transferase in Cells
O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect othe...
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| Publicado en: | Chem Commun (Camb) |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6823131/ https://ncbi.nlm.nih.gov/pubmed/31626249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc04560k |
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