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Targeted Covalent Inhibition of O-GlcNAc Transferase in Cells

O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect othe...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Worth, Matthew, Hu, Chia-Wei, Li, Hao, Fan, Dacheng, Estevez, Arielis, Zhu, Dongsheng, Wang, Ao, Jiang, Jiaoyang
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823131/
https://ncbi.nlm.nih.gov/pubmed/31626249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc04560k
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