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Targeted Covalent Inhibition of O-GlcNAc Transferase in Cells
O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect othe...
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| 出版年: | Chem Commun (Camb) |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6823131/ https://ncbi.nlm.nih.gov/pubmed/31626249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc04560k |
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