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Targeted Covalent Inhibition of O-GlcNAc Transferase in Cells

O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect othe...

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Bibliografiske detaljer
Udgivet i:Chem Commun (Camb)
Main Authors: Worth, Matthew, Hu, Chia-Wei, Li, Hao, Fan, Dacheng, Estevez, Arielis, Zhu, Dongsheng, Wang, Ao, Jiang, Jiaoyang
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823131/
https://ncbi.nlm.nih.gov/pubmed/31626249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc04560k
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