Canonical Wnt signaling induces vascular endothelial dysfunction via p66(Shc)-regulated reactive oxygen species

OBJECTIVE: Reactive oxygen species regulate canonical Wnt signaling. However, the role of the redox regulatory protein p66(Shc) in the canonical Wnt pathway is not known. We investigated if p66(Shc) is essential for canonical Wnt signaling in the endothelium and determined if the canonical Wnt pathw...

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Published in:Arterioscler Thromb Vasc Biol
Main Authors: Vikram, Ajit, Kim, Young-Rae, Kumar, Santosh, Naqvi, Asma, Hoffman, Timothy A., Kumar, Ajay, Miller, Francis J., Kim, Cuk-Seong, Irani, Kaikobad
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069972/
https://ncbi.nlm.nih.gov/pubmed/25147340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.304338
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