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HIV-1 gp41 Residues Modulate CD4-Induced Conformational Changes in the Envelope Glycoprotein and Evolution of a Relaxed Conformation of gp120

Entry of human immunodeficiency virus type 1 (HIV-1) into host cells is mediated by conformational changes in the envelope glycoprotein (Env) that are triggered by Env binding to cellular CD4 and chemokine receptors. These conformational changes involve the opening of the gp120 surface subunit, expo...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Keller, Paul W., Morrison, Orrianne, Vassell, Russell, Weiss, Carol D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6069199/
https://ncbi.nlm.nih.gov/pubmed/29875245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00583-18
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