Mutations That Increase the Stability of the Postfusion gp41 Conformation of the HIV-1 Envelope Glycoprotein Are Selected by both an X4 and R5 HIV-1 Virus To Escape Fusion Inhibitors Corresponding to Heptad Repeat 1 of gp41, but the gp120 Adaptive Mutations Differ between the Two Viruses

Binding of the gp120 surface subunit of the envelope glycoprotein (Env) of HIV-1 to CD4 and chemokine receptors on target cells triggers refolding of the gp41 transmembrane subunit into a six-helix bundle (6HB) that promotes fusion between virus and host cell membranes. To elucidate details of Env e...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Zhuang, Min, Vassell, Russell, Yuan, Chen, Keller, Paul W., Ling, Hong, Wang, Wei, Weiss, Carol D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532104/
https://ncbi.nlm.nih.gov/pubmed/30894471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00142-19
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