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An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules
Microtubule-based molecular motors mediate transport of intracellular cargo to subdomains in neurons. Previous evidence has suggested that the anesthetic propofol decreases the average run-length potential of the major anterograde transporters kinesin-1 and kinesin-2 without altering their velocity....
Guardat en:
| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6065180/ https://ncbi.nlm.nih.gov/pubmed/29844014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002182 |
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