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Common general anesthetic propofol impairs kinesin processivity

Propofol is the most widely used i.v. general anesthetic to induce and maintain anesthesia. It is now recognized that this small molecule influences ligand-gated channels, including the GABA(A) receptor and others. Specific propofol binding sites have been mapped using photoaffinity ligands and muta...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bensel, Brandon M., Guzik-Lendrum, Stephanie, Masucci, Erin M., Woll, Kellie A., Eckenhoff, Roderic G., Gilbert, Susan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448234/
https://ncbi.nlm.nih.gov/pubmed/28484025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701482114
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