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Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition
Propofol is a widely used intravenous general anesthetic. We synthesized 2-fluoro-1,3-diisopropylbenzene, a compound that we call “fropofol”, to directly assess the significance of the propofol 1-hydroxyl for pharmacologically relevant molecular recognition in vitro and for anesthetic efficacy in vi...
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| Publicado no: | ACS Chem Neurosci |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4936777/ https://ncbi.nlm.nih.gov/pubmed/25799399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00078 |
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