Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition

Propofol is a widely used intravenous general anesthetic. We synthesized 2-fluoro-1,3-diisopropylbenzene, a compound that we call “fropofol”, to directly assess the significance of the propofol 1-hydroxyl for pharmacologically relevant molecular recognition in vitro and for anesthetic efficacy in vi...

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Udgivet i:ACS Chem Neurosci
Main Authors: Woll, Kellie A., Weiser, Brian P., Liang, Qiansheng, Meng, Tao, McKinstry-Wu, Andrew, Pinch, Benika, Dailey, William P., Gao, Wei Dong, Covarrubias, Manuel, Eckenhoff, Roderic G.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936777/
https://ncbi.nlm.nih.gov/pubmed/25799399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00078
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