A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABA(A)), Receptor Subunit Binding Selectivity in Synaptosomes

Propofol, an intravenous anesthetic, is a positive modulator of the GABA(A) receptor, but the mechanistic details, including the relevant binding sites and alternative targets, remain disputed. Here we undertook an in-depth study of alkylphenol-based anesthetic binding to synaptic membranes. We desi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Woll, Kellie A., Murlidaran, Sruthi, Pinch, Benika J., Hénin, Jérôme, Wang, Xiaoshi, Salari, Reza, Covarrubias, Manuel, Dailey, William P., Brannigan, Grace, Garcia, Benjamin A., Eckenhoff, Roderic G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034043/
https://ncbi.nlm.nih.gov/pubmed/27462076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.736975
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