A Predicted Binding Site for Cholesterol on the GABA(A) Receptor

Modulation of the GABA type A receptor (GABA(A)R) function by cholesterol and other steroids is documented at the functional level, yet its structural basis is largely unknown. Current data on structurally related modulators suggest that cholesterol binds to subunit interfaces between transmembrane...

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Detalhes bibliográficos
Main Authors: Hénin, Jérôme, Salari, Reza, Murlidaran, Sruthi, Brannigan, Grace
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017285/
https://ncbi.nlm.nih.gov/pubmed/24806926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.03.024
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