A Predicted Binding Site for Cholesterol on the GABA(A) Receptor

Modulation of the GABA type A receptor (GABA(A)R) function by cholesterol and other steroids is documented at the functional level, yet its structural basis is largely unknown. Current data on structurally related modulators suggest that cholesterol binds to subunit interfaces between transmembrane...

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Hlavní autoři: Hénin, Jérôme, Salari, Reza, Murlidaran, Sruthi, Brannigan, Grace
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2014
Témata:
Channels and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017285/
https://ncbi.nlm.nih.gov/pubmed/24806926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.03.024
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