Interactions of L-3,5,3'-Triiodothyronine, Allopregnanolone, and Ivermectin with the GABA(A) Receptor: Evidence for Overlapping Intersubunit Binding Modes

Structural mechanisms of modulation of γ-aminobutyric acid (GABA) type A receptors by neurosteroids and hormones remain unclear. The thyroid hormone L-3,5,3’-triiodothyronine (T3) inhibits GABA(A) receptors at micromolar concentrations and has common features with neurosteroids such as allopregnanol...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Westergard, Thomas, Salari, Reza, Martin, Joseph V., Brannigan, Grace
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589331/
https://ncbi.nlm.nih.gov/pubmed/26421724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139072
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