Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling

In addition to inducing anesthesia, propofol activates a key component of the pain pathway, the transient receptor potential ankyrin 1 ion channel (TRPA1). Recent mutagenesis studies suggested a potential activation site within the transmembrane domain, near the A-967079 cavity. However, mutagenesis...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Woll, Kellie A., Skinner, Kenneth A., Gianti, Eleonora, Bhanu, Natarajan V., Garcia, Benjamin A., Carnevale, Vincenzo, Eckenhoff, Roderic G., Gaudet, Rachelle
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Biophysical Letters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700380/
https://ncbi.nlm.nih.gov/pubmed/28935134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.040
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