A carregar...
Propofol Inhibits SIRT2 Deacetylase through a Conformation-specific, Allosteric Site
meta-Azi-propofol (AziPm) is a photoactive analog of the general anesthetic propofol. We photolabeled a myelin-enriched fraction from rat brain with [(3)H]AziPm and identified the sirtuin deacetylase SIRT2 as a target of the anesthetic. AziPm photolabeled three SIRT2 residues (Tyr(139), Phe(190), an...
Na minha lista:
| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375505/ https://ncbi.nlm.nih.gov/pubmed/25666612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620732 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|