טוען...
Propofol Inhibits SIRT2 Deacetylase through a Conformation-specific, Allosteric Site
meta-Azi-propofol (AziPm) is a photoactive analog of the general anesthetic propofol. We photolabeled a myelin-enriched fraction from rat brain with [(3)H]AziPm and identified the sirtuin deacetylase SIRT2 as a target of the anesthetic. AziPm photolabeled three SIRT2 residues (Tyr(139), Phe(190), an...
שמור ב:
| הוצא לאור ב: | J Biol Chem |
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| Main Authors: | , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375505/ https://ncbi.nlm.nih.gov/pubmed/25666612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620732 |
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