An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules

Microtubule-based molecular motors mediate transport of intracellular cargo to subdomains in neurons. Previous evidence has suggested that the anesthetic propofol decreases the average run-length potential of the major anterograde transporters kinesin-1 and kinesin-2 without altering their velocity....

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Woll, Kellie A., Guzik-Lendrum, Stephanie, Bensel, Brandon M., Bhanu, Natarajan V., Dailey, William P., Garcia, Benjamin A., Gilbert, Susan P., Eckenhoff, Roderic G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065180/
https://ncbi.nlm.nih.gov/pubmed/29844014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002182
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