RalA controls glucose homeostasis by regulating glucose uptake in brown fat

Insulin increases glucose uptake into adipose tissue and muscle by increasing trafficking of the glucose transporter Glut4. In cultured adipocytes, the exocytosis of Glut4 relies on activation of the small G protein RalA by insulin, via inhibition of its GTPase activating complex RalGAP. Here, we ev...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Skorobogatko, Yuliya, Dragan, Morgan, Cordon, Claudia, Reilly, Shannon M., Hung, Chao-Wei, Xia, Wenmin, Zhao, Peng, Wallace, Martina, Lackey, Denise E., Chen, Xiao-Wei, Osborn, Olivia, Bogner-Strauss, Juliane G., Theodorescu, Dan, Metallo, Christian M., Olefsky, Jerrold M., Saltiel, Alan R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065037/
https://ncbi.nlm.nih.gov/pubmed/29915037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801050115
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