A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) for over a decade, but its treatment benefits are limited by acquired resistance, a process that remains incompletely understood. Here we report that an enhancer, located between the promoters of marker of proliferation Ki67 (MKI67)...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chen, Xiaoyue, Zhang, Minjie, Gan, Haiyun, Wang, Heping, Lee, Jeong-Heon, Fang, Dong, Kitange, Gaspar J., He, Lihong, Hu, Zeng, Parney, Ian F., Meyer, Fredric B., Giannini, Caterina, Sarkaria, Jann N., Zhang, Zhiguo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063898/
https://ncbi.nlm.nih.gov/pubmed/30054476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05373-4
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