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Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts

Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that rapamycin delays senescence in human cells and that...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Nacarelli, Timothy, Azar, Ashley, Altinok, Oya, Orynbayeva, Zulfiya, Sell, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060207/
https://ncbi.nlm.nih.gov/pubmed/29931650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-018-0030-2
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