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Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?
Unexpected activation of mTOR signaling, measured by ribosomal S6 phosphorylation or ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related settings. Evidence of elevated mTOR activity has been reported in heart and muscle tissue in aged mice and humans, mouse models of progeria,...
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| Publié dans: | Exp Gerontol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4589173/ https://ncbi.nlm.nih.gov/pubmed/25449851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2014.11.004 |
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