Inhibition of mTOR prevents ROS production initiated by ethidium bromide-induced mitochondrial DNA depletion.

The regulation of mitochondrial mass and DNA content involves a complex interaction between mitochondrial DNA replication machinery, functional components of the electron transport chain, selective clearance of mitochondria, and nuclear gene expression. In order to gain insight into cellular respons...

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Autores principales: Timothy eNacarelli, Ashley eAzar, Christian eSell
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2014-07-01
Colección:Frontiers in Endocrinology
Materias:
Aging
Mitochondria
senescence
mTOR
rapamycin
ROS
Acceso en línea:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00122/full
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