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Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

Coordinated expression of mitochondrial and nuclear genes is required to maintain proper mitochondrial function. However, the precise mechanisms that ensure this coordination are not well defined. We find that signaling from mitochondria to the nucleus is influenced by mammalian target of rapamycin...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Lerner, Chad, Bitto, Alessandro, Pulliam, Daniel, Nacarelli, Timothy, Konigsberg, Mina, Van Remmen, Holly, Torres, Claudio, Sell, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559196/
https://ncbi.nlm.nih.gov/pubmed/23795962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12122
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