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Targeting the Unique Mechanism of Bacterial 1-deoxy-D-xylulose 5-phosphate (DXP) Synthase

The bacterial metabolite 1-deoxy-D-xyulose-5-phosphate (DXP) is essential in bacterial central metabolism feeding into isoprenoid, thiamin diphosphate (ThDP), and pyridoxal phosphate de novo biosynthesis. Halting its production through the inhibition of DXP synthase is an attractive strategy for the...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Bartee, David, Freel Meyers, Caren L.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057799/
https://ncbi.nlm.nih.gov/pubmed/29944345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00548
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