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Targeting the Unique Mechanism of Bacterial 1-deoxy-D-xylulose 5-phosphate (DXP) Synthase

The bacterial metabolite 1-deoxy-D-xyulose-5-phosphate (DXP) is essential in bacterial central metabolism feeding into isoprenoid, thiamin diphosphate (ThDP), and pyridoxal phosphate de novo biosynthesis. Halting its production through the inhibition of DXP synthase is an attractive strategy for the...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Bartee, David, Freel Meyers, Caren L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057799/
https://ncbi.nlm.nih.gov/pubmed/29944345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00548
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