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Targeting the Unique Mechanism of Bacterial 1-deoxy-D-xylulose 5-phosphate (DXP) Synthase
The bacterial metabolite 1-deoxy-D-xyulose-5-phosphate (DXP) is essential in bacterial central metabolism feeding into isoprenoid, thiamin diphosphate (ThDP), and pyridoxal phosphate de novo biosynthesis. Halting its production through the inhibition of DXP synthase is an attractive strategy for the...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6057799/ https://ncbi.nlm.nih.gov/pubmed/29944345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00548 |
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