Restriction of Replication of Oncolytic Herpes Simplex Virus with a Deletion of γ34.5 in Glioblastoma Stem-Like Cells

Oncolytic viruses, including herpes simplex viruses (HSVs), are a new class of cancer therapeutic engineered to infect and kill cancer cells while sparing normal tissue. To ensure that oncolytic HSV (oHSV) is safe in the brain, all oHSVs in clinical trial for glioma lack the γ34.5 genes responsible...

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Vydáno v:J Virol
Hlavní autoři: Peters, Cole, Paget, Max, Tshilenge, Kizito-Tshitoko, Saha, Dipongkor, Antoszczyk, Slawomir, Baars, Anouk, Frost, Thomas, Martuza, Robert L., Wakimoto, Hiroaki, Rabkin, Samuel D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052301/
https://ncbi.nlm.nih.gov/pubmed/29793956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00246-18
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