Restriction of Replication of Oncolytic Herpes Simplex Virus with a Deletion of γ34.5 in Glioblastoma Stem-Like Cells

Oncolytic viruses, including herpes simplex viruses (HSVs), are a new class of cancer therapeutic engineered to infect and kill cancer cells while sparing normal tissue. To ensure that oncolytic HSV (oHSV) is safe in the brain, all oHSVs in clinical trial for glioma lack the γ34.5 genes responsible...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Peters, Cole, Paget, Max, Tshilenge, Kizito-Tshitoko, Saha, Dipongkor, Antoszczyk, Slawomir, Baars, Anouk, Frost, Thomas, Martuza, Robert L., Wakimoto, Hiroaki, Rabkin, Samuel D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052301/
https://ncbi.nlm.nih.gov/pubmed/29793956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00246-18
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