Effect of γ34.5 Deletions on Oncolytic Herpes Simplex Virus Activity in Brain Tumors

The ICP34.5 protein of herpes simplex virus (HSV) is involved in many aspects of viral pathogenesis; promoting neurovirulence, inhibiting interferon-induced shutoff of protein synthesis, interacting with PCNA and TBK1, inhibiting dendritic cell (DC) maturation, and binding to Beclin 1 to interfere w...

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Autors principals: Kanai, Ryuichi, Zaupa, Cecile, Sgubin, Donatella, Antoszczyk, Slawomir J., Martuza, Robert L., Wakimoto, Hiroaki, Rabkin, Samuel D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318611/
https://ncbi.nlm.nih.gov/pubmed/22345479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00017-12
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