Oncolytic Herpes Simplex Virus Counteracts the Hypoxia-Induced Modulation of Glioblastoma Stem-Like Cells

Glioblastoma (GBM), a fatal malignant brain tumor, contains abundant hypoxic regions that provide a “niche” to promote both the maintenance and enrichment of glioblastoma stem-like cells (GSCs) and confer resistance to chemo- and radiotherapy. Since GSCs, with an ability to resist conventional thera...

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Main Authors: Sgubin, Donatella, Wakimoto, Hiroaki, Kanai, Ryuichi, Rabkin, Samuel D., Martuza, Robert L.
Format: Artigo
Jezik:Inglês
Izdano: AlphaMed Press 2012
Teme:
Original Articles and Reviews
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659700/
https://ncbi.nlm.nih.gov/pubmed/23197811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2011-0035
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