In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells

On murine T cells, GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) ADP-ribosylates the P2X7 ion channel at arginine 125 in response to nicotinamide adenine dinucleotide (NAD(+)) released during cell preparation. We have previously shown that chronic gating of P2X7 by ADP-ribosylation reduces the v...

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Опубликовано в: :Front Immunol
Главные авторы: Rissiek, Björn, Lukowiak, Marco, Raczkowski, Friederike, Magnus, Tim, Mittrücker, Hans-Willi, Koch-Nolte, Friedrich
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046629/
https://ncbi.nlm.nih.gov/pubmed/30038627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01580
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