Astrocytes and Microglia Are Resistant to NAD(+)-Mediated Cell Death Along the ARTC2/P2X7 Axis

ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD(+)) triggers cell death. Since NAD(+) is released as a danger signal during tissue damage, this NAD(+)-induced cell d...

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Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Rissiek, Björn, Stabernack, Joschi, Cordes, Maike, Duan, Yinghui, Behr, Sarah, Menzel, Stephan, Magnus, Tim, Koch-Nolte, Friedrich
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971201/
https://ncbi.nlm.nih.gov/pubmed/32009900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00330
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