Extracellular NAD(+) shapes the Foxp3(+) regulatory T cell compartment through the ART2–P2X7 pathway

CD4(+)CD25(+)FoxP3(+) regulatory T cells (T reg cells) play a major role in the control of immune responses but the factors controlling their homeostasis and function remain poorly characterized. Nicotinamide adenine dinucleotide (NAD(+)) released during cell damage or inflammation results in ART2.2...

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Bibliographische Detailangaben
Hauptverfasser: Hubert, Sandra, Rissiek, Björn, Klages, Katjana, Huehn, Jochen, Sparwasser, Tim, Haag, Friedrich, Koch-Nolte, Friedrich, Boyer, Olivier, Seman, Michel, Adriouch, Sahil
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2010
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989765/
https://ncbi.nlm.nih.gov/pubmed/20975043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091154
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