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A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice
Among laboratory mouse strains many genes are differentially expressed in the same cell population. As consequence, gene targeting in 129-derived embryonic stem cells (ESCs) and backcrossing the modified mice onto the C57BL/6 background can introduce passenger mutations in the close proximity of the...
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| Publicado no: | iScience |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7733020/ https://ncbi.nlm.nih.gov/pubmed/33336163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101870 |
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