Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling

Foreign antigens are presented by antigen-presenting cells in the presence of abundant endogenous peptides that are nonstimulatory to the T cell. In mouse T cells, endogenous, nonstimulatory peptides have been shown to enhance responses to specific peptide antigens, a phenomenon termed coagonism. Ho...

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Vydáno v:Nat Commun
Hlavní autoři: Zhao, Xiang, Sankaran, Shvetha, Yap, Jiawei, Too, Chien Tei, Ho, Zi Zong, Dolton, Garry, Legut, Mateusz, Ren, Ee Chee, Sewell, Andrew K., Bertoletti, Antonio, MacAry, Paul A., Brzostek, Joanna, Gascoigne, Nicholas R. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045629/
https://ncbi.nlm.nih.gov/pubmed/30006605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05288-0
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