Optimized Peptide–MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

Peptide–MHC (pMHC) multimers have become the “gold standard” for the detection and isolation of antigen-specific T-cells but recent evidence shows that normal use of these reagents can miss fully functional T-cells that bear T-cell receptors (TCRs) with low affinity for cognate antigen. This issue i...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Dolton, Garry, Zervoudi, Efthalia, Rius, Cristina, Wall, Aaron, Thomas, Hannah L., Fuller, Anna, Yeo, Lorraine, Legut, Mateusz, Wheeler, Sophie, Attaf, Meriem, Chudakov, Dmitriy M., Choy, Ernest, Peakman, Mark, Sewell, Andrew K.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034003/
https://ncbi.nlm.nih.gov/pubmed/30008714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01378
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