Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations

Peptide-MHC (pMHC) multimers, usually used as streptavidin-based tetramers, have transformed the study of Ag-specific T cells by allowing direct detection, phenotyping, and enumeration within polyclonal T cell populations. These reagents are now a standard part of the immunology toolkit and have bee...

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Bibliographic Details
Published in:J Immunol
Main Authors: Rius, Cristina, Attaf, Meriem, Tungatt, Katie, Bianchi, Valentina, Legut, Mateusz, Bovay, Amandine, Donia, Marco, thor Straten, Per, Peakman, Mark, Svane, Inge Marie, Ott, Sascha, Connor, Tom, Szomolay, Barbara, Dolton, Garry, Sewell, Andrew K.
Format: Artigo
Language:Inglês
Published: AAI 2018
Subjects:
Antigen Recognition and Responses
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857646/
https://ncbi.nlm.nih.gov/pubmed/29483360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700242
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