Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases

Rhomboids are intramembrane serine proteases and belong to the group of structurally and biochemically most comprehensively characterized membrane proteins. They are highly conserved and ubiquitously distributed in all kingdoms of life and function in a wide range of biological processes, including...

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Publicado no:Biochemistry
Main Authors: Goel, Parul, Jumpertz, Thorsten, Mikles, David C., Tichá, Anezžka, Nguyen, Minh T. N., Verhelst, Steven, Hubalek, Martin, Johnson, Darren C., Bachovchin, Daniel A., Ogorek, Isabella, Pietrzik, Claus U., Strisovsky, Kvido, Schmidt, Boris, Weggen, Sascha
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040592/
https://ncbi.nlm.nih.gov/pubmed/29185711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01066
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