Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases

Rhomboid proteases are increasingly being explored as potential drug targets, but their potent and specific inhibitors are not available, and strategies for inhibitor development are hampered by the lack of widely usable and easily modifiable in vitro activity assays. Here we address this bottleneck...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Tichá, Anežka, Stanchev, Stancho, Škerle, Jan, Began, Jakub, Ingr, Marek, Švehlová, Kateřina, Polovinkin, Lucie, Růžička, Martin, Bednárová, Lucie, Hadravová, Romana, Poláchová, Edita, Rampírová, Petra, Březinová, Jana, Kašička, Václav, Majer, Pavel, Strisovsky, Kvido
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Methods and Resources
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314168/
https://ncbi.nlm.nih.gov/pubmed/28069810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762849
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