Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases

Rhomboid proteases are increasingly being explored as potential drug targets, but their potent and specific inhibitors are not available, and strategies for inhibitor development are hampered by the lack of widely usable and easily modifiable in vitro activity assays. Here we address this bottleneck...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tichá, Anežka, Stanchev, Stancho, Škerle, Jan, Began, Jakub, Ingr, Marek, Švehlová, Kateřina, Polovinkin, Lucie, Růžička, Martin, Bednárová, Lucie, Hadravová, Romana, Poláchová, Edita, Rampírová, Petra, Březinová, Jana, Kašička, Václav, Majer, Pavel, Strisovsky, Kvido
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Methods and Resources
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5314168/
https://ncbi.nlm.nih.gov/pubmed/28069810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762849
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