Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures

The mechanisms of intramembrane proteases are incompletely understood due to the lack of structural data on substrate complexes. To gain insight into substrate binding by rhomboid proteases, we have synthesised a series of novel peptidyl-chloromethylketone (CMK) inhibitors and analysed their interac...

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Publicado en:EMBO J
Autores principales: Zoll, Sebastian, Stanchev, Stancho, Began, Jakub, Škerle, Jan, Lepšík, Martin, Peclinovská, Lucie, Majer, Pavel, Strisovsky, Kvido
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253528/
https://ncbi.nlm.nih.gov/pubmed/25216680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489367
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