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Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures
The mechanisms of intramembrane proteases are incompletely understood due to the lack of structural data on substrate complexes. To gain insight into substrate binding by rhomboid proteases, we have synthesised a series of novel peptidyl-chloromethylketone (CMK) inhibitors and analysed their interac...
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| Pubblicato in: | EMBO J |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BlackWell Publishing Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253528/ https://ncbi.nlm.nih.gov/pubmed/25216680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489367 |
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