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Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures
The mechanisms of intramembrane proteases are incompletely understood due to the lack of structural data on substrate complexes. To gain insight into substrate binding by rhomboid proteases, we have synthesised a series of novel peptidyl-chloromethylketone (CMK) inhibitors and analysed their interac...
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| Udgivet i: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BlackWell Publishing Ltd
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4253528/ https://ncbi.nlm.nih.gov/pubmed/25216680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489367 |
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