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Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures

The mechanisms of intramembrane proteases are incompletely understood due to the lack of structural data on substrate complexes. To gain insight into substrate binding by rhomboid proteases, we have synthesised a series of novel peptidyl-chloromethylketone (CMK) inhibitors and analysed their interac...

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Библиографические подробности
Опубликовано в: :EMBO J
Главные авторы: Zoll, Sebastian, Stanchev, Stancho, Began, Jakub, Škerle, Jan, Lepšík, Martin, Peclinovská, Lucie, Majer, Pavel, Strisovsky, Kvido
Формат: Artigo
Язык:Inglês
Опубликовано: BlackWell Publishing Ltd 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253528/
https://ncbi.nlm.nih.gov/pubmed/25216680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489367
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