General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases

Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is curre...

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Publicat a:Cell Chem Biol
Autors principals: Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746060/
https://ncbi.nlm.nih.gov/pubmed/29107700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.007
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