General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases

Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is curre...

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Опубликовано в: :Cell Chem Biol
Главные авторы: Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746060/
https://ncbi.nlm.nih.gov/pubmed/29107700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.007
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