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Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

[Image: see text] Rhomboids are relatively recently discovered intramembrane serine proteases that are conserved throughout evolution. They have a wide range of biological functions, and there is also much speculation about their potential medical relevance. Although rhomboids are weakly inhibited b...

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Detalhes bibliográficos
Main Authors: Pierrat, Olivier A., Strisovsky, Kvido, Christova, Yonka, Large, Jonathan, Ansell, Keith, Bouloc, Nathalie, Smiljanic, Ela, Freeman, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077804/
https://ncbi.nlm.nih.gov/pubmed/21175222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100314y
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