Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

The high DNA specificity of homing endonucleases makes them a powerful protein scaffold to engineer enzymes for genome manipulation. Understanding their molecular recognition of DNA is an important prerequisite to generate engineered enzymes able to cleave DNA in specific desired genome sites. Prote...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Prieto, Jesús, Redondo, Pilar, López-Méndez, Blanca, D’Abramo, Marco, Merino, Nekane, Blanco, Francisco J., Duchateau, Phillipe, Montoya, Guillermo, Molina, Rafael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035192/
https://ncbi.nlm.nih.gov/pubmed/29980759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28599-0
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