Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening

Protein-protein interactions (PPIs) represent important and promising therapeutic targets that are associated with the regulation of various molecular pathways, particularly in cancer. Although they were once considered “undruggable,” the recent advances in screening strategies, structure-based desi...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Mady, Ahmed S. A., Liao, Chenzhong, Bajwa, Naval, Kump, Karson J., Abulwerdi, Fardokht A., Lev, Katherine L., Miao, Lei, Grigsby, Sierrah M., Perdih, Andrej, Stuckey, Jeanne A., Du, Yuhong, Fu, Haian, Nikolovska-Coleska, Zaneta
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033896/
https://ncbi.nlm.nih.gov/pubmed/29976942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27899-9
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